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Published trial averages: Semaglutide: ~1015% of body weight Tirzepatide: ~1522% of body weight A typical arc: minimal change during early titration, a steadier phase over the following months, then a maintenance phase

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Patients should contact their GP if they experience concerning symptoms and report suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

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At the same time, use of liraglutide, the previously dominant medication in the class sold as Victoza and Saxenda, fell sharply in both groups

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Community forums remain an invaluable resource for current updates and managing expectations

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